We create protein-based immunotherapies targeting the immune synapse to treat cancer and autoimmune/inflammatory disorders.
Alpine Immune Sciences capitalizes on our unique understanding of the immune synapse, using our directed evolution platform to engineer native immune system proteins for therapeutic benefit.
At Alpine Immune Sciences, we are applying our platform discovery technology to bring innovative new drugs to people living with cancer and autoimmune/inflammatory diseases
Alpine’s powerful directed evolution platform is based upon proteins native to the immune synapse, engineering potentially novel “Variant immunoglobulin domains” or “vIgDs”. Our vIgDs can engage multiple targets simultaneously, can be significantly more potent then native proteins, and have the potential improve therapeutic outcomes for the treatment of cancer and autoimmune/inflammatory conditions.
Because vIgDs are based upon natural participants in the immune synapse, they potentially provide a mechanistic advantage over larger, more artificial constructs.
ALPN-101 is a first-in-class dual CD28/ICOS antagonist being developed for the treatment of autoimmune and inflammatory diseases. A Phase 1 healthy volunteer study has been completed and we anticipate the start of ‘BALANCE’, a Phase 1b/2 clinical trial in GVHD, to begin in 2020.
ALPN-202 is a first-in-class conditional CD28 costimulator and dual checkpoint inhibitor being developed for the treatment of cancer. We anticipate a Phase 1 trial in cancer patients to begin in 2020.
Our Transmembrane Immunomodulatory Protein (TIP) program potentially enhances Engineered Cellular Therapies (ECTs) like CAR-T, TCR, and TIL. TIPs are based upon our core vIgD technology, but are engineered to become part of ECTs to potentially increase specificity, persistence, and/or efficacy.