Scientific Publications

Povetacicept (ALPN-303)

All publications

European Renal Association (ERA) 2024

Updated results of povetacicept, an enhanced dual BAFF/APRIL antagonist, in IgA nephropathy (RUBY-3)

May 2024

National Kidney Foundation (NKF) Spring Clinical Meeting 2024

Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in Autoantibody-Associated Glomerulonephritis

May 2024

American Academy of Neurology (AAN) 2024

Povetacicept(ALPN-303), a Potent Dual BAFF/APRIL Antagonist, Suppresses Disease in a Mouse Model of Autoimmune Encephalitis

April 2024

World Congress of Nephrology (WCN) 2024

Updated Results from the RUBY-3 Study of Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in IgA Nephropathy

April 2024

European Lupus Meeting (SLEuro) 2024

The Enhanced Dual BAFF/APRIL Inhibitor Povetacicept (TACI vTD-Fc; ALPN-303) More Potently Reduces Disease Activity in Murine Lupus Compared to CD20 Depletion and WT TACI-Ig, Associated with Greater End-Organ Distribution

March 2024

Chinese Society of Nephrology 2023

Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in Autoantibody-Associated Glomerulonephritis

December 2023

American College of Rheumatology (ACR) 2023

Upregulation of Both APRIL and BAFF in Systemic Lupus Erythematosus Suggests Non-Redundant Roles, Further Revealed by Dual Inhibition with Povetacicept (ALPN-303)

November 2023

American Academy of Neuromuscular & Electrodiagnostic Medicine (AANEM) 2023

Povetacicept (ALPN-303), a Potent Dual BAFF/APRIL Antagonist, for the Treatment of Myasthenia Gravis and Other Antibody-Related Neurological Diseases

November 2023

American Society of Nephrology (ASN) Kidney Week 2023

Povetacicept, an Enhanced Dual BAFF/APRIL Antagonist, in Autoantibody-Associated Glomerulonephritis

November 2023

American Conference on Pharmacometrics 2023

Clinical Pharmacokinetic/Pharmacodynamic Modeling of Povetacicept, a
Potent Dual BAFF/APRIL Antagonist, to inform Dose Selection in
Autoimmune Diseases

November 2023

American Neurological Association 2023

Povetacicept (ALPN-303), a Potent Dual BAFF/APRIL Antagonist, for the Treatment of Myasthenia Gravis (MG) and Other Antibody-Related Neurological Diseases

September 2023

American College of Clinical Pharmacology 2023

Clinical Pharmacokinetic/Pharmacodynamic Modeling of Povetacicept, a Potent Dual BAFF/APRIL Antagonist, to Inform Dose Selection in Autoimmune Diseases

September 2023

European Renal Association (ERA) 2023

Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Povetacicept (ALPN-303), a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Glomerulonephritides

June 2023

European Hematology Association (EHA) 2023

Povetacicept (ALPN-303), a Potent Dual BAFF/APRIL Antagonist, for the Treatment of Autoimmune Cytopenias and Other Antibody-Related Diseases

June 2023

European Alliance of Associations for Rheumatology (EULAR) 2023

A Placebo-Controlled Phase 1 Study in Healthy Adult Volunteers of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Povetacicept (ALPN-303), a Potent Dual BAFF/APRIL Antagonist, for the Treatment of Systemic Lupus Erythematosus and Other B Cell-Related Disorders (RUBY-1)

June 2023

International Congress on Systemic Lupus Erythematosus/Korean College of Rheumatology 2023

A Placebo-Controlled Phase 1 Study in Healthy Adult Volunteers of the Safety,
Tolerability, Pharmacokinetics, and Pharmacodynamics of Povetacicept, a Potent
Dual BAFF/APRIL Antagonist, for the Treatment of Systemic Lupus Erythematosus

May 2023

Korean Society of Nephrology (KSN) 2023

Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Povetacicept (ALPN-303), a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Glomerulonephritides

April 2023

World Congress of Nephrology (WCN) 2023

Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, & Pharmacodynamics of ALPN-303, a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Glomerulonephritides

March 2023

American Society for Clinical Pharmacology & Therapeutics (ASCPT) 2023

Early Clinical PK/PD Modeling and Simulation of Povetacicept, a Potent Dual BAFF/APRIL Antagonist, to Support Clinical Trials in Multiple Autoantibody- and/or B Cell-Related Diseases

March 2023

American Academy of Dermatology (AAD) 2023

Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Povetacicept (ALPN-303), a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Blistering Diseases (RUBY-1)

March 2023

Arthritis & Rheumatology

Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist that Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases

Jan 2023

ASH Annual Meeting & Exposition

A Randomized, Placebo-Controlled, Phase 1 Study in Healthy Adult Volunteers of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALPN-303, a Potent Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Cytopenias

Dec 2022

American College of Rheumatology Convergence

A Randomized Placebo-Controlled Phase 1 Study in Healthy Adult Volunteers of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ALPN-303, a Potent Dual BAFF/APRIL Antagonist for the Treatment of Systemic Lupus Erythematosus and Other Autoantibody-Associated Diseases

Nov 2022

American Society of Nephrology Kidney Week

Phase 1 Study in Healthy Adults of the Safety, Tolerability, Pharmacokinetics, & Pharmacodynamics of ALPN-303, a Dual BAFF/APRIL Antagonist for the Treatment of Autoimmune Glomerulonephritides (GN)

Nov 2022

European Lupus Meeting

A Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Pharmacodynamics of ALPN-303, a Potent Dual BAFF/APRIL Inhibitor, in Adult Healthy Volunteers (RUBY-1)

Oct 2022

European Alliance of Associations for Rheumatology

ALPN-303, an Engineered Dual BAFF/APRIL Antagonist, Potently Inhibits Pathogenic Autoantibodies in Preclinical Models, with Corresponding Pharmacodynamic Activity in Humans

Jun 2022

American College of Rheumatology

ALPN-303, an Enhanced, Potent Dual BAFF/APRIL Antagonist Engineered by Directed Evolution for the Treatment of Systemic Lupus Erythematosus (SLE) and Other B Cell-Related Diseases

Nov 2021

European Alliance of Associations for Rheumatology

ALPN-303, an Enhanced, Potent Dual BAFF/APRIL Antagonist Engineered by Directed Evolution for the Treatment of Systemic Lupus Erythematosus (SLE) and Other B Cell-Related Autoimmune Diseases

Jun 2021

European Alliance of Associations for Rheumatology

B Cell Modulatory Variant TNF Receptor Domains (vTDs) Identified by Directed Evolution to Inhibit BAFF and APRIL, Alone or Combined with Variant Ig Domains (vIgD™) that Inhibit T Cell Costimulation, for the Treatment of Systemic Lupus Erythematosus and Other Severe Autoimmune Diseases

Jun 2020

Acazicolcept (ALPN-101)

All publications

American College of Rheumatology (ACR) 2023

Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101) Reveals Non-Redundant Roles of T Cell Costimulation Pathways in Systemic Lupus Erythematosus

November 2023

Association for Research in Vision and Ophthalmology

Systemic Administration of Acazicolcept(ALPN-101), a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis

May 2022

Arthritis Research & Therapy

Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models

Jan 2022

Transplantation & Cellular Therapy

ALPN-101 (ICOSL vIgD Fc), a Dual Antagonist of the ICOS and CD28 Costimulatory Pathways, for Treatment of Steroid Refractory Acute GVHD ( aGVHD ): Case Report

Feb 2021

Clinical and Translational Science

First-in-human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects

Jan 2021

Science Translational Medicine

ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

Oct 2020

European Alliance of Associations for Rheumatology

A Double Blind, Placebo Controlled, Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of ALPN-101, a First-In-Class Dual ICOS/CD28 Antagonist, in Healthy Volunteers (HV)

Jun 2020

Crohn’s and Colitis Congress

ALPN-101, A First-In-Class Dual ICOS/CD28 Antagonist, Demonstrates Efficacy In Patient-Derived PBMC In Vitro And In an In Vivo T Cell Transfer Model Of Chronic Inflammatory Bowel Disease (IBD)

Jan 2020

American Society of Hematology

An Open Label Study of ALPN-101, a First in Class Dual CD28/ICOS Antagonist, in Subjects with Steroid Resistant or Steroid Refractory Acute Graft Versus Host Disease (BALANCE)

Dec 2019

American College of Rheumatology

ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Associated with Sjögren’s Syndrome and Systemic Lupus Erythematosus

Nov 2019

American College of Rheumatology

ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Underlying Rheumatoid and Psoriatic Arthritis

Nov 2019

Protein Engineering Summit

Protein Engineering by Directed Evolution to Derive ALPN-101, a Dual ICOS/CD28 Antagonist ICOSL Variant Ig Domain (vIgD)-Fc Fusion Protein for the Treatment of Inflammatory Diseases

Apr 2019

Transplantation & Cellular Therapy

ALPN-101, a Dual ICOS/CD28 Antagonist, Demonstrates Potent and Dose-Dependent Suppression of Graft vs. Host Disease (GvHD) in a Human/NSGTM Mouse Xenograft Model, with Activity Superior to CD28 or ICOS Single Pathway Antagonists

Feb 2019

American Society of Hematology

Therapeutic Candidate ALPN-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)

Dec 2018

American College of Rheumatology

ALPN-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Disease in Multiple Mouse Models of Autoimmunity

Oct 2018

American Neurological Society

Therapeutic Candidate ALPN-101, a Dual ICOS/CD28 Antagonist, Demonstrates In Vivo Efficacy in an Experimental Autoimmune Encephalomyelitis (EAE) Model

Oct 2018

American Society of Hematology

Novel Variant Ig Domain (vIgD) Proteins Generated Via Directed Evolution of IgSF Domains Have Therapeutic Efficacy in Animal Models of Graft Versus Host Disease

Dec 2017

Alpine Platform and Other Publications

All publications

American Society of Clinical Oncology

TPS2683: Davoceticept (ALPN-202), a PD-L1-dependent CD28 Costimulator and Dual Checkpoint Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Malignancies (NEON-2)

Jun 2022

American Society of Clinical Oncology

2560: Dose Escalation of Davoceticept, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, in Advanced Malignancies (NEON-1)

Jun 2022

American Association for Cancer Research

Monotherapy dose escalation of davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1)

Apr 2022

Nature Communications

The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity

Apr 2022

Society for Immunotherapy of Cancer

Development of a Clinical Ex Vivo Assay for the Assessment of Therapeutic CD28 Costimulatory Pathway Engagement

Nov 2021

Society for Immunotherapy of Cancer

A Study of ALPN-202, a PD-L1-dependent CD28 Costimulator and Dual Checkpoint Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Malignancies (NEON-2)

Nov 2021

American Society of Clinical Oncology

First in Human Dose Escalation of ALPN-202, A Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, in Advanced Malignancies (NEON-1)

Jun 2021

American Association of Cancer Research

NEON-1: A First-in-Human Phase I Open-Label Study of ALPN-202, a Conditional CD28 Costimulatorand Dual Checkpoint Inhibitor, in Advanced Malignancies

Apr 2021

American Association of Cancer Research

Engineered Variant Domain Fusion Proteins Provide Checkpoint Inhibition and Tumor Antigen-Dependent CD28 Costimulation Resulting in Potent Anti-Tumor Immunity

Apr 2021

American Association of Cancer Research

NEON-1: A first in human phase I open label study of ALPN 202, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies

Apr 2020

United States and Canada Pathology Association

Development of Novel Monoclonal Antibodies for the Robust Detection of CD28, CD80, and CD86 by Immunohistochemistry in Human Tumors

Mar 2020

American Association of Cancer Research

ALPN-202 Combines Checkpoint Inhibition with Conditional T Cell Costimulation to Overcome T Cell Suppression by M2c Macrophages and Improve the Durability of Engineered T Cell Anti-Tumor Responses

Jun 2020

Society for the Immunotherapy of Cancer

ALPN-202, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, Utilizes Multiple Mechanisms to Elicit Potent Anti-Tumor Immunity Superior to Checkpoint Blockade

Nov 2019

Society for the Immunotherapy of Cancer

ALPN-202, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, Enhances the Activity of Multiple Standard of Care Modalities

Nov 2019

American Society of Hematology

“Switch” Transmembrane Immunomodulatory Proteins (TIPs) Consisting of High-Affinity PD-1 Extracellular Domains (PD-1 vIgDs) and Costimulatory Intracellular Domains Potently Enhance the Activity of TCR-Engineered T Cells

Dec 2018