Scientific Publications
Clinical publications
ALPN-101 (ICOSL vIgD Fc), a Dual Antagonist of the ICOS and CD28 Costimulatory Pathways, for Treatment of Steroid Refractory Acute GVHD ( aGVHD ): Case Report
First-in-human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects
A Double Blind, Placebo Controlled, Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) Study of ALPN-101, a First-In-Class Dual ICOS/CD28 Antagonist, in Healthy Volunteers (HV)
An Open Label Study of ALPN-101, a First in Class Dual CD28/ICOS Antagonist, in Subjects with Steroid Resistant or Steroid Refractory Acute Graft Versus Host Disease (BALANCE)
Preclinical publications
Systemic Administration of Acazicolcept(ALPN-101), a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis
Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models
ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist
ALPN-101, A First-In-Class Dual ICOS/CD28 Antagonist, Demonstrates Efficacy In Patient-Derived PBMC In Vitro And In an In Vivo T Cell Transfer Model Of Chronic Inflammatory Bowel Disease (IBD)
ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Associated with Sjögren’s Syndrome and Systemic Lupus Erythematosus
ALPN-101, a First-in-Class Dual ICOS/CD28 Antagonist, Suppresses Key Effector Mechanisms Underlying Rheumatoid and Psoriatic Arthritis
Protein Engineering by Directed Evolution to Derive ALPN-101, a Dual ICOS/CD28 Antagonist ICOSL Variant Ig Domain (vIgD)-Fc Fusion Protein for the Treatment of Inflammatory Diseases
ALPN-101, a Dual ICOS/CD28 Antagonist, Demonstrates Potent and Dose-Dependent Suppression of Graft vs. Host Disease (GvHD) in a Human/NSGTM Mouse Xenograft Model, with Activity Superior to CD28 or ICOS Single Pathway Antagonists
Therapeutic Candidate ALPN-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Human/NSG Mouse Xenograft Graft vs. Host Disease (GvHD) in a Dose Ranging Study and Reduces Disease Activity in a Mouse Model of Hemophagocytic Lymphohistiocytosis (HLH)
ALPN-101, a Dual ICOS/CD28 Antagonist, Potently Suppresses Disease in Multiple Mouse Models of Autoimmunity
Therapeutic Candidate ALPN-101, a Dual ICOS/CD28 Antagonist, Demonstrates In Vivo Efficacy in an Experimental Autoimmune Encephalomyelitis (EAE) Model
Novel Variant Ig Domain (vIgD) Proteins Generated Via Directed Evolution of IgSF Domains Have Therapeutic Efficacy in Animal Models of Graft Versus Host Disease
Davoceticept (ALPN-202)
Clinical publications
2560: Dose Escalation of Davoceticept, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, in Advanced Malignancies (NEON-1)
TPS2683: Davoceticept (ALPN-202), a PD-L1-dependent CD28 Costimulator and Dual Checkpoint Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Malignancies (NEON-2)
Monotherapy dose escalation of davoceticept (ALPN-202), a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies (NEON-1)
A Study of ALPN-202, a PD-L1-dependent CD28 Costimulator and Dual Checkpoint Inhibitor, in Combination with Pembrolizumab in Patients with Advanced Malignancies (NEON-2)
First in Human Dose Escalation of ALPN-202, A Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, in Advanced Malignancies (NEON-1)
NEON-1: A First-in-Human Phase I Open-Label Study of ALPN-202, a Conditional CD28 Costimulatorand Dual Checkpoint Inhibitor, in Advanced Malignancies
NEON-1: A first in human phase I open label study of ALPN 202, a conditional CD28 costimulator and dual checkpoint inhibitor, in advanced malignancies
Preclinical publications
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
Development of a Clinical Ex Vivo Assay for the Assessment of Therapeutic CD28 Costimulatory Pathway Engagement
ALPN-202 Combines Checkpoint Inhibition with Conditional T Cell Costimulation to Overcome T Cell Suppression by M2c Macrophages and Improve the Durability of Engineered T Cell Anti-Tumor Responses
Development of Novel Monoclonal Antibodies for the Robust Detection of CD28, CD80, and CD86 by Immunohistochemistry in Human Tumors
ALPN-202, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, Utilizes Multiple Mechanisms to Elicit Potent Anti-Tumor Immunity Superior to Checkpoint Blockade
ALPN-202, a Conditional CD28 Costimulator and Dual Checkpoint Inhibitor, Enhances the Activity of Multiple Standard of Care Modalities
ALPN-303
ALPN-303, an Engineered Dual BAFF/APRIL Antagonist, Potently Inhibits Pathogenic Autoantibodies in Preclinical Models, with Corresponding Pharmacodynamic Activity in Humans
ALPN-303, an Enhanced, Potent Dual BAFF/APRIL Antagonist Engineered by Directed Evolution for the Treatment of Systemic Lupus Erythematosus (SLE) and Other B Cell-Related Diseases
ALPN-303, an Enhanced, Potent Dual BAFF/APRIL Antagonist Engineered by Directed Evolution for the Treatment of Systemic Lupus Erythematosus (SLE) and Other B Cell-Related Autoimmune Diseases
B Cell Modulatory Variant TNF Receptor Domains (vTDs) Identified by Directed Evolution to Inhibit BAFF and APRIL, Alone or Combined with Variant Ig Domains (vIgD™) that Inhibit T Cell Costimulation, for the Treatment of Systemic Lupus Erythematosus and Other Severe Autoimmune Diseases
Alpine Platform and Other Publications
Engineered Variant Domain Fusion Proteins Provide Checkpoint Inhibition and Tumor Antigen-Dependent CD28 Costimulation Resulting in Potent Anti-Tumor Immunity
“Switch” Transmembrane Immunomodulatory Proteins (TIPs) Consisting of High-Affinity PD-1 Extracellular Domains (PD-1 vIgDs) and Costimulatory Intracellular Domains Potently Enhance the Activity of TCR-Engineered T Cells