About Us

Join us in the discovery and development of next-generation immunotherapies.

Who We Are

Alpine Immune Sciences is a clinical stage biopharmaceutical company dedicated to discovering and developing innovative, protein-based immunotherapies. Launched in 2015, we have created and advanced multiple product candidates into clinical trials for inflammatory/autoimmune diseases and cancer, formed collaborations with world-class partners, and built a robust development pipeline.

Our scientific platform consists of unique protein engineering strategies, including the directed evolution of immune proteins into novel, multi-targeted therapeutics. With such differentiated candidates, we hope to improve outcomes in patients with cancer and severe inflammatory/autoimmune diseases.

Our employees (Alpinists) are passionately committed to creating new therapies for patients living with cancer and inflammatory/autoimmune diseases. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with inspiring views and an open design to facilitate teamwork. Our job listings are available below.

At Alpine, we strive to create a safe, respectful, and inspiring environment in which our team members engage openly and honestly with each other, bringing their work and life experiences to the table.

We seek to lead the next evolution of immunotherapies powered by the diversity of our therapeutic libraries and approaches. We also understand that our success equally relies on the diversity of our team and are committed to building an organization in which everyone has a voice, and we strive for a diversity of backgrounds.

Values

The Alpine Timeline

2015

  • Operations begin

2016

  • $48 million series A financing

2017

  • Completed reverse merger to become publicly listed company (NASDAQ: ALPN)

2019

  • Acazicolcept (ALPN-101) phase 1 initiation

2019

  • $25 million private placement
  • Adaptimmune collaboration and license agreement

2020

  • Acazicolcept phase 1 EULAR presentation
  • Davoceticept (ALPN-202) phase 1 initiation

2020

  • AbbVie agreement for up to $865 million, with $60 million upfront
  • $60 million private placement

2021

  • Davoceticept ASCO presentation
  • ALPN-303 ACR presentation and phase 1 healthy volunteer initiation

2021

  • $45 million AbbVie milestone
  • Merck collaboration and supply agreement for NEON-2 study
  • $91 million private placement
  • Horizon Therapeutics agreement for up to $1.52 billion, with $25 million upfront and $15 million equity investment

2022

  • Davoceticept NEON-1 dose escalation complete & Nature Communications
  • ALPN-303 EULAR preclinical and preliminary phase 1 data

2022

  • Appointed Andrew Sandler, MD as Chief Medical Officer
  • Appointed Jörn Drappa, MD, PhD to Board of Directors
  • Completed ~$113M follow-on offering in Q3 2022

Alpine Values (Our DNA)​​​​​​​

We are better together

  • We work collaboratively
  • We challenge and support each other

We are courageous

  • We take calculated risks to make big advancements in our work
  • We prioritize and do what matters

We are nimble and move quickly

  • We are action oriented and do what it takes to get the job done
  • We adapt to change

We are scientific pioneers

  • We are breaking new ground
  • We engineer first-in-class molecules

Join us in the discovery and development of next-generation immunotherapies.

Current job openings